When the opiate receptor depends on G protein coupling for signal transduction, this receptor was identified to benefit from arrestin activation for internalization from the receptor. In any other case, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable improvement in binding efficacy. https://rafaelhfpye.blogocial.com/little-known-facts-about-conoldine-alternative-natural-pain-relief-74245813