Schematic illustration of activated and inhibited Wnt/β-catenin pathway. “WNT ON state�? Upon ligation of Wnts for their receptors composed of frizzled proteins and LRP5/6, the cytoplasmic protein DVL is activated and induces the suppression of GSK3β. Subsequently, stabilized β-catenin translocates into the nucleus and binds to TCF/LEF transcription factors to https://johnn429dhk2.ageeksblog.com/profile